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Hwi Jin Ko

1-1-6 Project Director

  • Affiliation SNU (Bio-Max/N-Bio)
  • Tel +82-2-880-1506
  • E-mail

    hwijinko@snu.ac.kr

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  • Research TopicDevelopment of supersensitive biosensor for biomedical diagnosis and water quality assessment system using human olfactory receptor
Project : Development of supersensitive biosensor for biomedical diagnosis and water quality assessment system using human olfactory receptor
Purpose ○ This research aims at the development of supersensitive biosensor for biomedical diagnosis and water quality assessment system using human olfactory receptor which have characteristics as follows :
- A biosensor system which has the ability of extremely sensitive detection of
biomarkers in urine of tuberculosis patients
- A sensor system which has the ability of qualitative and quantitative
measurement of water contaminants with high sensitivity
- Development of multi-channel sensor system for simultaneous detection of various
biomarkers and water pollutants
Contents ○ Construction of human olfactory receptor library
- Acquisition of olfactory receptor genes from human genome
- Cloning of olfactory receptor genes to an expression vector
○ Development of artificial olfactory cell and screening of human olfactory receptor
- Development of the artificial olfactory cell which has the same signaling mechanism as the human olfactory cell
- Selection of the human olfactory receptor showing a specific response with tuberculosis biomarkers and water pollutants
○ Establishment of ultra-sensitive biosensor systems for detecting tuberculosis biomarkers and water pollutants
- Construction of nanovesicles containing human olfactory receptor derived from artificial olfactory cells
- Production of nanomaterial-based sensor platforms with olfactory nanovesicles
- Construction of biosensor system which has high selectivity of human olfactory receptor and high sensitivity of nanomaterial-based platforms
○ Development of multi-channel sensor system
- Various kinds of human olfactory receptor-based multi-channel biosensor
- Detection of various tuberculosis biomarkers and water pollutants with a
multi-channel biosensor system
Expected Contribution ○ Human olfactory receptor can selectively detect biomarkers and water pollutants in real sample with a high selectivity
○ Nanomaterial-based biosensor can detect , which is ultra sensitive material, will be able to detect the concentration of detection limit for tuberculosis disease diagnosis and water quality assessment with an ultra-sensitivity
○ Non-invasive disease diagnosis will be available with tuberculosis patients urine
○ Real-time monitoring of water pollution will be achieved without any pre-treatment procedures
Publication
No Title Year Phase
1 Coupling of Olfactory Receptor and Ion Channel for Rapid and Sensitive Visualization of Odorant Response 2015.08. Phase 2
2nd year
1
Patent
No Title Country Date Phase
 
Conference
No title Conference Name Date Phase
 
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